Nuclear export of the DEAD box An3 protein by CRM1 is coupled to An3 helicase activity.

Abstract

We have recently identified the Xenopus laevis An3 protein as a bona fide substrate for the nuclear export receptor CRM1 (Exportin 1). An3 binds directly to CRM1 with high affinity via a leucine-rich nuclear export signal located in the extreme N terminus. An3 is a member of the DEAD box family of RNA helicases, which unwind RNA duplexes. RNA unwinding is… (More)

Topics

Cite this paper

@article{Askjaer2000NuclearEO, title={Nuclear export of the DEAD box An3 protein by CRM1 is coupled to An3 helicase activity.}, author={Peter Askjaer and Riitta Rosendahl and J\orgen Kjems}, journal={The Journal of biological chemistry}, year={2000}, volume={275 16}, pages={11561-8} }