Nuclear export of mRNA by TAP/NXF1 requires two nucleoporin-binding sites but not p15.

@article{Braun2002NuclearEO,
  title={Nuclear export of mRNA by TAP/NXF1 requires two nucleoporin-binding sites but not p15.},
  author={Isabelle C Braun and Andrea Herold and Michaela Rode and Elisa Izaurralde},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 15},
  pages={5405-18}
}
Metazoan NXF1/p15 heterodimers promote export of bulk mRNA through nuclear pore complexes (NPC). NXF1 interacts with the NPC via two distinct structural domains, the UBA-like domain and the NTF2-like scaffold, which results from the heterodimerization of the NTF2-like domain of NXF1 with p15. Both domains feature a single nucleoporin-binding site, and they act synergistically to promote NPC translocation. Whether the NTF2-like scaffold (and thereby p15) contributes only to NXF1/NPC association… CONTINUE READING
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