Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway.

@article{Fridell1996NuclearEO,
  title={Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway.},
  author={Robert A. Fridell and Hal P. Bogerd and Bryan R Cullen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 9},
  pages={4421-4}
}
The Rev protein of HIV-1 is essential for the nuclear export of incompletely spliced viral mRNAs. This action depends on the mutationally defined Rev activation domain, which both binds the nucleoporin-like human cellular cofactor Rab/hRIP and also functions as a nuclear export signal. Protein kinase inhibitor alpha (PKI) also contains a potent nuclear export signal. However, PKI plays no role in nuclear RNA export and instead induces the nuclear export of a specific protein target, the… CONTINUE READING

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