Nuclear export of RNA

  title={Nuclear export of RNA},
  author={Manuel S Rodr{\'i}guez and Catherine Dargemont and Françoise Stutz},
  journal={Biology of the Cell},

Transporting RNAs from Nucleus to the Cytoplasm

The discussion involves the description of the cisand transrequirements for mRNA export as well as the different mechanisms of recruiting export factors to mRNPs.

Dynamics and kinetics of nucleo‐cytoplasmic mRNA export

The steps taken by an mRNA molecule in transit to the nuclear envelope and during mRNA export are delineated, with specific focus on the dynamic aspects of nucleo‐cytoplasmic mRNA transport as revealed by electron microscopy and live‐cell imaging.

Quality control of messenger ribonucleoprotein particles in the nucleus and at the pore.

Biogenesis of mRNPs: integrating different processes in the eukaryotic nucleus

The overall process of mR NP biogenesis is reviewed with particular emphasis on the functional coupling of transcription with mRNP biogenesis and export and its relationship to nuclear organization.

Exporting RNA from the nucleus to the cytoplasm

The transport of RNA molecules from the nucleus to the cytoplasm is fundamental for gene expression and understanding the mechanisms that connect RNP formation with export is a major challenge in the field.

RNA in cells

In the last few years new classes of regulatory non-coding RNAs have been discovered: small interfering RNAs (siRNAs) and microRNAs (miRNAs).

Structures of the tRNA export factor in the nuclear and cytosolic states

The binding mode explains how Xpot can recognize all mature tRNAs in the cell and yet distinguish them from those that have not been properly processed, thus coupling tRNA export to quality control.

Nuclear Export of Proteins and RNA

Findings show that cold, stress, or phytohormone signaling cascades and the control of flowering are especially sensitive to impaired mRNA biogenesis and export.

Transcription and transport of a messenger RNP particle : Novel regulatory mechanisms

Novel mechanisms for the regulation of BR RNP particle transcription and transport are identified and a transcript-specific hnRNP protein, hrp130, present along the Balbiani ring 3 gene is identified, similar to the human protein CA150 that works as a repressor of transcription elongation.



Pre-mRNA processing factors are required for nuclear export.

Analysis of mRNA nuclear export in living yeast cells shows the connections between mRNA processing and nuclear export.

The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus

The findings suggest that the RNA1 protein is not directly involved in RNA processing but may modify nuclear proteins or otherwise transmit a signal from the cytosol to the nucleus or play a role in maintaining the integrity of the nucleus.

Transport between the cell nucleus and the cytoplasm.

A focus of this review is nuclear export of messenger RNA, which apparently largely relies on export mediators distinct from importin beta-related factors.

Mature mRNA 3′ end formation stimulates RNA export from the nucleus.

The results demonstrate that sequences directing either histone mRNA 3′ processing or cleavage/polyadenylation of mRNA stimulate nucleocytoplasmic RNA transport, and provide genetic evidence that there is a linkage between 3′ end formation and the export of RNA transcripts from the nucleus.

Exportin-5 Mediates Nuclear Export of Minihelix-containing RNAs*

In vivo and in vitro competition experiments using various VA1-derived, but also artificial and cellular, RNAs lead to the conclusion that exportin-5 preferentially recognizes and transports minihelix motif-containing RNAs.

Role of polyadenylation in nucleocytoplasmic transport of mRNA

It is suggested that polyadenylation is required for the nucleocytoplasmic transport of mRNA and that Rev interaction with the Rev-responsive element cannot bypass this requirement.