Nuclear export complexes in the frame.

@article{Cook2010NuclearEC,
  title={Nuclear export complexes in the frame.},
  author={Atlanta G Cook and Elena Conti},
  journal={Current opinion in structural biology},
  year={2010},
  volume={20 2},
  pages={
          247-52
        }
}
Protein and RNA molecules are exchanged between the nucleus and cytoplasm by members of the karyopherin beta family of transport factors. Karyopherins adopt a modular HEAT-repeat architecture and are regulated by the GTPase Ran. RanGTP acts as a signal for the nuclear compartment, dissociating molecular cargo from karyopherins that mediate nuclear import and promoting cargo uptake on those mediating nuclear export. After unraveling the mechanisms of nuclear import factors, structural studies… CONTINUE READING
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