Nuclear exclusion of wild-type p53 in immortalized human retinoblastoma cells.

@article{Schlamp1997NuclearEO,
  title={Nuclear exclusion of wild-type p53 in immortalized human retinoblastoma cells.},
  author={Cassandra L. Schlamp and Gretchen L. Poulsen and T. Michael Nork and Robert W Nickells},
  journal={Journal of the National Cancer Institute},
  year={1997},
  volume={89 20},
  pages={1530-6}
}
BACKGROUND Retinoblastoma is the most common childhood tumor of the eye, arising from cells that are defective in both copies of the retinoblastoma susceptibility gene (RB1). Most retinoblastoma tumor cells eventually undergo programmed cell death (i.e., apoptosis); however, some cells can acquire the ability to metastasize and become immortal. Transfection… CONTINUE READING