Nuclear exclusion of SMAD2/3 in granulosa cells is associated with primordial follicle activation in the mouse ovary.

@article{Hardy2018NuclearEO,
  title={Nuclear exclusion of SMAD2/3 in granulosa cells is associated with primordial follicle activation in the mouse ovary.},
  author={Kate Hardy and Jocelyn M. Mora and Carina M. Dunlop and Raffaella Carzaniga and Stephen Franks and Mark A Fenwick},
  journal={Journal of cell science},
  year={2018},
  volume={131 17}
}
Maintenance and activation of the limited supply of primordial follicles in the ovary are important determinants of reproductive lifespan. Currently, the molecular programme that maintains the primordial phenotype and the early events associated with follicle activation are not well defined. Here, we have systematically analysed these events using microscopy and detailed image analysis. Using the immature mouse ovary as a model, we demonstrate that the onset of granulosa cell (GC) proliferation… CONTINUE READING