Nuclear envelope defects impede a proper response to micronuclear DNA lesions.

@article{Terradas2012NuclearED,
  title={Nuclear envelope defects impede a proper response to micronuclear DNA lesions.},
  author={Mariona Terradas and Marta L{\'o}pez Mart{\'i}n and Laia Hern{\'a}ndez and Laura Tusell and Anna Genesc{\`a}},
  journal={Mutation research},
  year={2012},
  volume={729 1-2},
  pages={35-40}
}
When damage is inflicted in nuclear DNA, cells activate a hierarchical plethora of proteins that constitute the DNA damage response machinery. In contrast to the cell nucleus, the ability of micronuclear DNA lesions to activate this complex network is controversial. In order to determine whether the DNA contained in micronuclei is protected by the cellular damage response system, we studied the recruitment of excision repair factors to photolesions inflicted in the DNA of radiation-induced… CONTINUE READING

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