Nuclear effects: unexpected intracellular actions of insulin-like growth factor binding protein-3.

@article{Lee2002NuclearEU,
  title={Nuclear effects: unexpected intracellular actions of insulin-like growth factor binding protein-3.},
  author={K W Lee and Pinchas Cohen},
  journal={The Journal of endocrinology},
  year={2002},
  volume={175 1},
  pages={33-40}
}
Insulin-like growth factor (IGF) binding protein (IGFBP)-3 has been shown to be a growth inhibitory, apoptosis-inducing molecule by virtue of its ability to bind IGFs, in addition to previously demonstrated IGF-independent effects. The recent discovery of the interaction between nuclear IGFBP-3 and 9-cis retinoic acid receptor-alpha (retinoid X receptor alpha RXRalpha), a nuclear receptor, and its involvement in the regulation of transcriptional signaling and apoptosis represents an important… CONTINUE READING

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