Nuclear domains enriched in RNA 3'-processing factors associate with coiled bodies and histone genes in a cell cycle-dependent manner.

@article{Schul1999NuclearDE,
  title={Nuclear domains enriched in RNA 3'-processing factors associate with coiled bodies and histone genes in a cell cycle-dependent manner.},
  author={Wouter Schul and Ineke van der Kraan and A Gregory Matera and Roel van Driel and Luitzen de Jong},
  journal={Molecular biology of the cell},
  year={1999},
  volume={10 11},
  pages={
          3815-24
        }
}
Nuclear domains, called cleavage bodies, are enriched in the RNA 3'-processing factors CstF 64 kDa and and CPSF 100 kDa. Cleavage bodies have been found either overlapping with or adjacent to coiled bodies. To determine whether the spatial relationship between cleavage bodies and coiled bodies was influenced by the cell cycle, we performed cell synchronization studies. We found that in G1 phase cleavage bodies and coiled bodies were predominantly coincident, whereas in S phase they were mostly… CONTINUE READING

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