Nuclear distribution of the Ki-67 antigen during the cell cycle: comparison with growth fraction in human breast cancer cells.

@article{Dierendonck1989NuclearDO,
  title={Nuclear distribution of the Ki-67 antigen during the cell cycle: comparison with growth fraction in human breast cancer cells.},
  author={Jan Hein van Dierendonck and Rob Keijzer and Cornelius J H van de Velde and Cees J. Cornelisse},
  journal={Cancer research},
  year={1989},
  volume={49 11},
  pages={2999-3006}
}
It has been claimed that the commercially available Ki-67 monoclonal antibody recognizes a nuclear antigen which is solely expressed in cycling cells. Therefore, at present, Ki-67 is increasingly used as a tool in evaluating growth fractions (GFs) of human tumors. Here we describe specific patterns in the expression and topological distribution of this antigen during the cell cycle in MCF-7 human breast cancer cells. Our results support earlier findings that the antigen belongs to a class of… CONTINUE READING
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Subdivision of S - phase by analysis of nuclear BrdUrd staining patterns

  • J. H. Van Dierendonck, R. Keijzer, C. J. H. Van de Velde, C. J. Cornelisse
  • Cytometry
  • 1989

Subdivision of S-phase by analysis of nuclear BrdUrd staining

  • J. H. Van Dierendonck, R. Keijzer, C.J.H. Van de Velde, C. J. Cornelisse
  • patterns. Cytometry,
  • 1989
2 Excerpts

ci'j-Diaminedichloroplatinum(II)-resistant sublines derived from two human ovarian tumor cell lines

  • P.J.K. Kuppen, H. Schuitmaker, L. J. Van 't Veer, E. A. De Bruijn, A. T. Van Oosterom, P. I. Schrier
  • Cancer Res.,
  • 1988
1 Excerpt

Characterization of a slowgrowing, transplantable rat mammary tumor (MCR-83): a model for endo crine-related cell kinetic studies

  • J. H. Van Dierendonck, C. J. Cornelisse, P.W.G. Van der Linden, L. M. Van Putten, C.J.H. Van de Velde
  • Cancer Res.,
  • 1987
1 Excerpt

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