Nuclear cloning of embryonal carcinoma cells.

  title={Nuclear cloning of embryonal carcinoma cells.},
  author={Robert Blelloch and Konrad Hochedlinger and Yasuhiro Yamada and C. V. Weiss Brennan and Minjung Kim and Beatrice Mintz and Lynda Chin and Rudolf Jaenisch},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 39},
Embryonal carcinoma (EC) cells have served as a model to study the relationship between cancer and cellular differentiation given their potential to produce tumors and, to varying degrees, participate in embryonic development. Here, nuclear transplantation was used to assess the extent to which the tumorigenic and developmental potential of EC cells is governed by epigenetic as opposed to genetic alterations. Nuclei from three independent mouse EC cell lines (F9, P19, and METT-1) with differing… CONTINUE READING