Nuclear architecture dictates HIV-1 integration site selection

@article{Marini2015NuclearAD,
  title={Nuclear architecture dictates HIV-1 integration site selection},
  author={Bruna Marini and Attila Kert{\'e}sz-Farkas and Hashim Ali and Bojana Lucic and Kamil Lisek and Lara Manganaro and S{\'a}ndor Pongor and Roberto Luzzati and Alessandra Recchia and Fulvio Mavilio and Mauro Giacca and Marina Lusic},
  journal={Nature},
  year={2015},
  volume={521},
  pages={227-231}
}
Long-standing evidence indicates that human immunodeficiency virus type 1 (HIV-1) preferentially integrates into a subset of transcriptionally active genes of the host cell genome. However, the reason why the virus selects only certain genes among all transcriptionally active regions in a target cell remains largely unknown. Here we show that HIV-1 integration occurs in the outer shell of the nucleus in close correspondence with the nuclear pore. This region contains a series of cellular genes… 
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