Nuclear and cell membrane effects contribute independently to the induction of apoptosis in human cells exposed to UVB radiation.

@article{Kulms1999NuclearAC,
  title={Nuclear and cell membrane effects contribute independently to the induction of apoptosis in human cells exposed to UVB radiation.},
  author={Dagmar Kulms and Birgit Poeppelmann and Daniel B. Yarosh and Thomas Anton Luger and Jean Krutmann and Thomas Schwarz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 14},
  pages={7974-9}
}
UVB-induced DNA damage is a crucial event in UVB-mediated apoptosis. On the other hand, UVB directly activates death receptors on the cell surface including CD95, implying that UVB-induced apoptosis can be initiated at the cell membrane through death receptor clustering. This study was performed to measure the relative contribution of nuclear and membrane effects in UVB-induced apoptosis of the human epithelial cell line HeLa. UVB-mediated DNA damage can be reduced by treating cells with… CONTINUE READING