Nuclear activation and translocation of mitogen-activated protein kinases modulated by ethanol in embryonic liver cells.

@article{Reddy2000NuclearAA,
  title={Nuclear activation and translocation of mitogen-activated protein kinases modulated by ethanol in embryonic liver cells.},
  author={M Abhilash Reddy and Shivendra D. Shukla},
  journal={Biochimica et biophysica acta},
  year={2000},
  volume={1497 2},
  pages={
          271-8
        }
}
Activation and nuclear translocation of mitogen activated protein (MAP) kinases in ethanol-treated embryonic liver cells (BNLCL2) was investigated. The relative amount of MAPK proteins, MAP kinase activity and MAPK/LDH (lactate dehydrogenase) ratios were determined in nuclear and cytosolic fractions before and after serum stimulation. In ethanol-treated cells, serum-stimulated MAPK activation was potentiated in both cytosolic and nuclear fractions. Levels of both the p42 and p44 MAPK proteins… CONTINUE READING
BETA

Similar Papers

Loading similar papers…