Nuclear actin and myosin I are required for RNA polymerase I transcription

@article{Philimonenko2004NuclearAA,
  title={Nuclear actin and myosin I are required for RNA polymerase I transcription},
  author={Vlada V. Philimonenko and Jian Zhao and Sebastian Iben and Hana Dingov{\'a} and Katarina Gaplovska Kysela and Michal Kahle and H. Zentgraf and Wilma A Hofmann and Primal de Lanerolle and Pavel Hoz{\'a}k and Ingrid Grummt},
  journal={Nature Cell Biology},
  year={2004},
  volume={6},
  pages={1165-1172}
}
The presence of actin and nuclear myosin I (NMI) in the nucleus suggests a role for these motor proteins in nuclear functions. We have investigated the role of actin and nuclear myosin I (NMI) in the transcription of ribosomal RNA genes (rDNA). Both proteins are associated with rDNA and are required for RNA polymerase I (Pol I) transcription. Microinjection of antibodies against actin or NMI, as well as short interfering RNA-mediated depletion of NMI, decreased Pol I transcription in vivo… CONTINUE READING
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