Nuclear actin and myosin I are required for RNA polymerase I transcription

@article{Philimonenko2004NuclearAA,
  title={Nuclear actin and myosin I are required for RNA polymerase I transcription},
  author={V. Philimonenko and Jian Zhao and S. Iben and H. Dingov{\'a} and Katar{\'i}na Kysel{\'a} and M. Kahle and H. Zentgraf and W. Hofmann and P. Lanerolle and P. Hoz{\'a}k and I. Grummt},
  journal={Nature Cell Biology},
  year={2004},
  volume={6},
  pages={1165-1172}
}
The presence of actin and nuclear myosin I (NMI) in the nucleus suggests a role for these motor proteins in nuclear functions. We have investigated the role of actin and nuclear myosin I (NMI) in the transcription of ribosomal RNA genes (rDNA). Both proteins are associated with rDNA and are required for RNA polymerase I (Pol I) transcription. Microinjection of antibodies against actin or NMI, as well as short interfering RNA-mediated depletion of NMI, decreased Pol I transcription in vivo… Expand
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References

SHOWING 1-10 OF 41 REFERENCES
Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II
An actin–ribonucleoprotein interaction is involved in transcription by RNA polymerase II
hRRN3 is essential in the SL1‐mediated recruitment of RNA Polymerase I to rRNA gene promoters
Transcription of mouse rDNA is regulated by an activated subform of RNA polymerase I
A growth‐dependent transcription initiation factor (TIF‐IA) interacting with RNA polymerase I regulates mouse ribosomal RNA synthesis.
An actin-myosin complex on actively transcribing genes.
Purification, assay, and properties of RNA polymerase I and class I-specific transcription factors in mouse.
Rrn3 Phosphorylation Is a Regulatory Checkpoint for Ribosome Biogenesis*
Factor C*, the specific initiation component of the mouse RNA polymerase I holoenzyme, is inactivated early in the transcription process.
p53 represses ribosomal gene transcription
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