Nuclear accumulation of beta-catenin in intestinal-type gastric carcinoma: correlation with early tumor invasion

@article{Miyazawa2000NuclearAO,
  title={Nuclear accumulation of beta-catenin in intestinal-type gastric carcinoma: correlation with early tumor invasion},
  author={Kenshi Miyazawa and Keiichi Iwaya and Masahiko Kuroda and Miki Harada and Hiromi Serizawa and Yasuhisa Koyanagi and Yu-ichi Sato and Yuji Mizokami and Takeshi Matsuoka and Kiyoshi Mukai},
  journal={Virchows Archiv},
  year={2000},
  volume={437},
  pages={508-513}
}
Mutation of the adenomatous polyposis coli gene, which is known to be an early event in the carcinogenesis of intestinal-type gastric carcinoma, leads to accumulation of beta-catenin. In addition, beta-catenin has been found to activate down stream signaling molecules in the wingless/Wnt pathway. In this study, the clinical significance of nuclear accumulation of beta-catenin was evaluated in gastric carcinoma. Immunohistochemical staining showed nuclear localization in 16 (12%) of 139 (94… CONTINUE READING
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