Nuclear accumulation of beta-catenin in intestinal-type gastric carcinoma: correlation with early tumor invasion

@article{Miyazawa2000NuclearAO,
  title={Nuclear accumulation of beta-catenin in intestinal-type gastric carcinoma: correlation with early tumor invasion},
  author={K. Miyazawa and K. Iwaya and M. Kuroda and M. Harada and H. Serizawa and Y. Koyanagi and Y. Sato and Y. Mizokami and T. Matsuoka and K. Mukai},
  journal={Virchows Archiv},
  year={2000},
  volume={437},
  pages={508-513}
}
  • K. Miyazawa, K. Iwaya, +7 authors K. Mukai
  • Published 2000
  • Biology, Medicine
  • Virchows Archiv
  • Abstract. Mutation of the adenomatous polyposis coli gene, which is known to be an early event in the carcinogenesis of intestinal-type gastric carcinoma, leads to accumulation of beta-catenin. In addition, beta-catenin has been found to activate down stream signaling molecules in the wingless/Wnt pathway. In this study, the clinical significance of nuclear accumulation of beta-catenin was evaluated in gastric carcinoma. Immunohistochemical staining showed nuclear localization in 16 (12%) of… CONTINUE READING

    Figures, Tables, and Topics from this paper.

    Loss of beta-catenin expression in metastatic gastric cancer.
    • 90
    Wnt/beta-catenin signaling pathway as a novel cancer drug target.
    • 226
    • PDF
    β-Catenin and the morphogenesis of colorectal cancer
    • 91

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 37 REFERENCES