Nuclear Transport: A Switch for the Oxidative Stress—Signaling Circuit?

  title={Nuclear Transport: A Switch for the Oxidative Stress—Signaling Circuit?},
  author={Mohamed Kodiha and Ursula Stochaj},
  booktitle={Journal of signal transduction},
Imbalances in the formation and clearance of reactive oxygen species (ROS) can lead to oxidative stress and subsequent changes that affect all aspects of physiology. To limit and repair the damage generated by ROS, cells have developed a multitude of responses. A hallmark of these responses is the activation of signaling pathways that modulate the function of downstream targets in different cellular locations. To this end, critical steps of the stress response that occur in the nucleus and… CONTINUE READING
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