Nuclear STAT3 translocation in guinea pig and rat brain endothelium during systemic challenge with lipopolysaccharide and interleukin-6.

@article{Rummel2005NuclearST,
  title={Nuclear STAT3 translocation in guinea pig and rat brain endothelium during systemic challenge with lipopolysaccharide and interleukin-6.},
  author={Christoph Daniel Rummel and Thomas Voss and Kioyoshi Matsumura and Stefan Korte and Ruediger Gerstberger and Joachim Roth and Thomas H{\"u}bschle},
  journal={The Journal of comparative neurology},
  year={2005},
  volume={491 1},
  pages={
          1-14
        }
}
During systemic inflammation, cytokines are released by immune-competent cells into the circulation, which in turn signal the brain to mediate brain-controlled signs of illness. Cytokine-responsive brain cells can be mapped by histological analysis of cytokine-induced transcription factors or transcription factor-associated molecules revealing different cell phenotypes that respond to activation of the immune system. Critical sites mediating cytokine-dependent immuneffector functions can be… CONTINUE READING
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