Nuclear Retention of Unspliced mRNAs in Yeast Is Mediated by Perinuclear Mlp1

Abstract

The molecular mechanism underlying the retention of intron-containing mRNAs in the nucleus is not understood. Here, we show that retention of intron-containing mRNAs in yeast is mediated by perinuclearly located Mlp1. Deletion of MLP1 impairs retention while having no effect on mRNA splicing. The Mlp1-dependent leakage of intron-containing RNAs is increased… (More)
DOI: 10.1016/S0092-8674(03)01026-2

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