Nuclear Receptors, Inflammation, and Liver Disease: Insights for Cholestatic and Fatty Liver Diseases

@article{Arrese2010NuclearRI,
  title={Nuclear Receptors, Inflammation, and Liver Disease: Insights for Cholestatic and Fatty Liver Diseases},
  author={M. Arrese and S. Karpen},
  journal={Clinical Pharmacology & Therapeutics},
  year={2010},
  volume={87}
}
  • M. Arrese, S. Karpen
  • Published 2010
  • Biology, Medicine
  • Clinical Pharmacology & Therapeutics
  • Members of the nuclear receptor (NR) superfamily of ligand‐activated transcription factors are players of substantial relevance in the regulation of hepatic gene expression. NRs direct normal physiology and metabolism, adaptations to liver disease, and responses to inflammation and toxins. They also contribute to the regenerative response. In this review, we summarize currently available experimental and clinical data, focusing on the role of NRs in cholestasis and nonalcoholic fatty liver… CONTINUE READING
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    References

    SHOWING 1-10 OF 44 REFERENCES
    The farnesoid X receptor (FXR) as a new target in non-alcoholic steatohepatitis.
    • B. Cariou
    • Biology, Medicine
    • Diabetes & metabolism
    • 2008
    • 47
    • PDF
    New molecular insights into the mechanisms of cholestasis.
    • 192
    • PDF
    Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis
    • 318
    • PDF
    Nuclear receptors as therapeutic targets in cholestatic liver diseases
    • 125
    • PDF