Nuclear Receptor Minireview Series*

@article{Olefsky2001NuclearRM,
  title={Nuclear Receptor Minireview Series*},
  author={Jerrold M. Olefsky},
  journal={The Journal of Biological Chemistry},
  year={2001},
  volume={276},
  pages={36863 - 36864}
}
  • J. Olefsky
  • Published 2001
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
The nuclear receptor superfamily describes a related but diverse array of transcription factors, which include nuclear hormone receptors (NHRs) and orphan nuclear receptors. NHRs are receptors for which hormonal ligands have been identified, whereas orphan receptors are so named because their ligands are unknown, at least at the time the receptor is identified. Unlike hormones for cell surface receptors, lipophilic hormones can traverse the plasma membrane to the cell interiors where NHRs… Expand
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A comprehensive mechanistic view of agonist and antagonist action will be presented and the novel class of partial agonists-antagonists will be described and the multiple challenges and novel perspectives for nuclear-receptor-based drug design will be discussed. Expand
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