Nuclear Receptor Minireview Series*

  title={Nuclear Receptor Minireview Series*},
  author={Jerrold M. Olefsky},
  journal={The Journal of Biological Chemistry},
  pages={36863 - 36864}
  • J. Olefsky
  • Published 2001
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
The nuclear receptor superfamily describes a related but diverse array of transcription factors, which include nuclear hormone receptors (NHRs) and orphan nuclear receptors. NHRs are receptors for which hormonal ligands have been identified, whereas orphan receptors are so named because their ligands are unknown, at least at the time the receptor is identified. Unlike hormones for cell surface receptors, lipophilic hormones can traverse the plasma membrane to the cell interiors where NHRs… Expand
RanBPM, a Nuclear Protein That Interacts with and Regulates Transcriptional Activity of Androgen Receptor and Glucocorticoid Receptor*
RanBPM interacts with steroid receptors to selectively modify their activity and is identified as a novel AR-interacting protein by yeast two-hybrid assay and confirmed by glutathione S-transferase- and His-tagged pull-down assays. Expand
ATVB in Focus Nuclear Receptors in Metabolism and Cardiovascular Disease
Members of the nuclear hormone receptor superfamily, including the peroxisome proliferator–activated receptor and the liver X receptor subfamilies, orchestrate transcriptional networks involved inExpand
NR4A orphan nuclear receptors: transcriptional regulators of gene expression in metabolism and vascular biology.
Recent advances in understanding the molecular biology and physiological functions of NR4A receptors are summarized and their role in the transcriptional control of metabolism and vascular remodeling is discussed. Expand
Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects.
The purpose of this review is to highlight the structural and molecular bases of CAR and PXR impact on human health, providing information on mechanisms through which diet, chemical exposure, and environment ultimately impact health and disease. Expand
Allosteric pathways in nuclear receptors — Potential targets for drug design
  • E. Fernandez
  • Biology, Medicine
  • Pharmacology & therapeutics
  • 2018
There is a growing interest in determining the genome‐scale impact of allostery in nuclear receptors, and biophysical studies are attempting to determine how these pathways that regulate co‐activator and DNA recognition can control gene transcription. Expand
Inter-species functional interactome of nuclear steroid receptors (R1).
These mechanisms provide an explanatory mechanism of the major Public Health problem of "non-ionizing" radiation impact, surpassing the existing conflict over the "thermal"/ " non- thermal" consequences of radiation, linking all the so far proposed mechanisms, and addressing all reported effects in humans, rodents and insects. Expand
Nuclear Receptors: Small Molecule Sensors that Coordinate Growth, Metabolism and Reproduction.
The Nuclear Receptor superfamily is reviewed to highlight both the common as well as newly emerging traits and functions that characterize this particularly unique and important TF family. Expand
The Multifaceted Mechanisms of Estradiol and Estrogen Receptor Signaling*
This minireview will discuss the recent progress toward the understanding of the molecular mechanisms of estrogen signaling, focusing on the following four pathways: 1) classical ligand-dependent; 2) ligand -independent; 3) DNA binding-independent; and 4) cell-surface (nongenomic) signaling. Expand
Transmembrane helices in “classical” nuclear reproductive steroid receptors: a perspective
Using computational methods to analyze peptide receptor topology, it is found that the “classical” nuclear receptors for progesterone, androgen and estrogen contain two transmembrane helices (TMH) within their ligand-binding domains (LBD). Expand
Modulation of Xenobiotic Receptors by Steroids
This review discusses functional interactions and their implications for activities mediated by steroid receptors and xenobiotic receptors, focusing on steroids that modulate pathways involving the pregnane X receptor and constitutive androstane receptor. Expand


Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications.
A comprehensive mechanistic view of agonist and antagonist action will be presented and the novel class of partial agonists-antagonists will be described and the multiple challenges and novel perspectives for nuclear-receptor-based drug design will be discussed. Expand
The nuclear receptor superfamily: The second decade
This research presents a new probabilistic procedure called ‘spot-spot analysis’ to characterize the response of the immune system to the presence of E.coli. Expand