Nuclear PLCs affect insulin secretion by targeting PPARγ in pancreatic β cells.

@article{Fiume2012NuclearPA,
  title={Nuclear PLCs affect insulin secretion by targeting PPARγ in pancreatic β cells.},
  author={Roberta Fiume and Giulia Ramazzotti and Irene Faenza and Manuela Piazzi and Alberto Bavelloni and Anna Maria Billi and Lucio Cocco},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2012},
  volume={26 1},
  pages={203-10}
}
Type 2 diabetes is a heterogeneous disorder caused by concomitant impairment of insulin secretion by pancreatic β cells and of insulin action in peripheral target tissues. Studies with inhibitors and agonists established a role for PLC in the regulation of insulin secretion but did not distinguish between effects due to nuclear or cytoplasmic PLC signaling pathways that act in a distinct fashion. We report that in MIN6 β cells, PLCβ1 localized in both nucleus and cytoplasm, PLCδ4 in the nucleus… CONTINUE READING

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