Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

  title={Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation},
  author={Weiwei Yang and Yan Xia and Haitao Ji and Yanhua Zheng and Ji Feng Liang and Wenhua Huang and Xiang Gao and Kenneth D. Aldape and Zhimin Lu},
The embryonic pyruvate kinase M2 (PKM2) isoform is highly expressed in human cancer. In contrast to the established role of PKM2 in aerobic glycolysis or the Warburg effect, its non-metabolic functions remain elusive. Here we demonstrate, in human cancer cells, that epidermal growth factor receptor (EGFR) activation induces translocation of PKM2, but not PKM1, into the nucleus, where K433 of PKM2 binds to c-Src-phosphorylated Y333 of β-catenin. This interaction is required for both proteins to… CONTINUE READING