Nuclear Magnetic Resonance-Based Dissection of a Glycosyltransferase Specificity for the Mucin MUC 1 Tandem Repeat †

@inproceedings{BrokxNuclearMR,
  title={Nuclear Magnetic Resonance-Based Dissection of a Glycosyltransferase Specificity for the Mucin MUC 1 Tandem Repeat †},
  author={Richard D. Brokx and Leigh Revers and Qinghong Zhang and Shaoxian Yang and Tapas Kumar Mal and Mitsuhiko Ikura}
}
The human glycoprotein MUC1 mucin plays a critical role in cancer progression. Breast, ovarian, and colon cancer cells often display unique cell-surface antigens corresponding to aberrantly glycosylated forms of the MUC1 tandem repeat. In this report, 15Nand 13C-labeled forms of a recombinant MUC1 construct containing five tandem repeats were used as substrates to define the order and kinetics of addition of N-acetylgalactosamine (GalNAc) moieties by a recombinant active form of the human… CONTINUE READING
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