Nuclear MTA1 overexpression is associated with aggressive prostate cancer, recurrence and metastasis in African Americans

@inproceedings{Dias2013NuclearMO,
  title={Nuclear MTA1 overexpression is associated with aggressive prostate cancer, recurrence and metastasis in African Americans},
  author={Steven J. Dias and Xinchun Zhou and Marina Ivanovi{\'c} and Michael P. Gailey and Swati Dhar and Liangfen Zhang and Zhi Hua He and Alan D. Penman and Srinivasan Vijayakumar and Anait S Levenson},
  booktitle={Scientific reports},
  year={2013}
}
Metastasis-associated protein 1 (MTA1), a negative epigenetic modifier, plays a critical role in prostate cancer (PCa) progression. We hypothesized that MTA1 overexpression in primary tumor tissues can predict PCa aggressiveness and metastasis. Immunohistochemical staining of MTA1 was done on archival PCa specimens from University of Mississippi Medical Center and University of Iowa. We found that nuclear MTA1 overexpression was positively correlated with the severity of disease progression… CONTINUE READING
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