Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis.

@article{Reaves2017NuclearLL,
  title={Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis.},
  author={Denise K. Reaves and Katherine A. Hoadley and Katerina D. Fagan-Solis and Dereje D. Jima and Michael Bereman and Lynnelle W. Thorpe and Jyla Hicks and David A. Mcdonald and Melissa A. Troester and Charles M. Perou and Jodie M Fleming},
  journal={Molecular cancer research : MCR},
  year={2017},
  volume={15 2},
  pages={
          165-178
        }
}
Lipolysis-stimulated lipoprotein receptor (LSR) has been found in the plasma membrane and is believed to function in lipoprotein endocytosis and tight junctions. Given the impact of cellular metabolism and junction signaling pathways on tumor phenotypes and patient outcome, it is important to understand how LSR cellular localization mediates its functions. We conducted localization studies, evaluated DNA binding, and examined the effects of nuclear LSR in cells, xenografts, and clinical… CONTINUE READING

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