Nuclear Legumain Activity in Colorectal Cancer

  title={Nuclear Legumain Activity in Colorectal Cancer},
  author={Mads Haugland Haugen and Harald Thidemann Johansen and Solveig J. Pettersen and Rigmor Solberg and Klaudia Brix and Kjersti Flatmark and Gunhild Mari Maelandsmo},
  booktitle={PloS one},
The cysteine protease legumain is involved in several biological and pathological processes, and the protease has been found over-expressed and associated with an invasive and metastatic phenotype in a number of solid tumors. Consequently, legumain has been proposed as a prognostic marker for certain cancers, and a potential therapeutic target. Nevertheless, details on how legumain advances malignant progression along with regulation of its proteolytic activity are unclear. In the present work… CONTINUE READING
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