Nuclear Inclusions and Pseudoinclusions: Friends or Foes of the Surgical Pathologist?

@article{Ip2010NuclearIA,
  title={Nuclear Inclusions and Pseudoinclusions: Friends or Foes of the Surgical Pathologist?},
  author={Yiu-Tung Ip and Marco Antonio Dias Filho and John Kwok-cheung Chan},
  journal={International Journal of Surgical Pathology},
  year={2010},
  volume={18},
  pages={465 - 481}
}
Abnormal substances in the nuclei that can be observed by light microscopy are often broadly referred to as nuclear inclusions. Although their recognition in the appropriate clinicopathological settings can aid in the diagnosis of some disease entities and tumor types, they can also be a source of error. There are 2 morphologically distinct types of inclusions with different mechanisms of formation and diagnostic significance, including bona fide nuclear inclusions and nuclear pseudoinclusions… 
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Pulmonary neuroendocrine tumors with nuclear inclusion.
Intranuclear inclusions in hepatocellular carcinoma contain autophagy‐associated proteins and correlate with prolonged survival
TLDR
It is demonstrated that intranuclear inclusions in hepatocellular carcinoma are true inclusions, completely closed and delimited by the nuclear membrane, containing degenerate cell organelles and lysosomal proteins, and proposed that the presence of autophagy‐associated proteins and proteases within the inclusions contribute to beneficial survival.
Ubiquitin Immunostaining in Thyroid Neoplasms Marks True Intranuclear Cytoplasmic Pseudoinclusions and May Help Differentiate Papillary Carcinoma from NIFTP
TLDR
Using strict histologic criteria and ubiquitin immunostaining, the presence of true pseudoinclusions may exclude a diagnosis of NIFTP, and the difference between true INCPs (found only in PTC) and pseudo-pseudoinclusions (found in NifTP) is supported.
Cytological, histological and ultrastructural nuclear features of monster cells in a canine carotid body carcinoma.
Nuclear Bubbles (Nuclear Pseudo-Pseudoinclusions): A Pitfall in the Interpretation of Microscopic Sections From the Thyroid and Other Human Organs.
TLDR
Genomic heterogeneity of translocation renal cell carcinoma and alveolar soft part sarcoma: a distinctive tumor entity previously included among renal cell cancers of children and adolescents.
New insights into intranuclear inclusions in thyroid carcinoma: Association with autophagy and with BRAFV600E mutation
TLDR
The presence of autophagy-associated proteins within the NI together with degenerated organelles and lysosomal proteases suggests their involvement in Autophagy and proteolysis.
Nuclear pseudoinclusions in melanoma cells: prognostic fact or artifact? The possible role of Golgi phosphoprotein 3 overexpression in nuclear pseudoinclusions generation
TLDR
Positive associations with shorter cancer‐specific survival, but not disease‐free survival are observed and the possible explanation of NPI generation is associated with enhanced activity of Golgi apparatus in melanoma cells.
Chan Eosin Stain in Diagnostic Surgical Pathology − The Wonderful Colors of the Hematoxylin
TLDR
The spectrum, intensity, and texture of colors observed in H&E-stained slides are discussed to illustrate their value in surgical pathology diagnosis.
Characterization of two types of intranuclear hepatocellular inclusions in NAFLD
TLDR
Two morphologically different types of inclusions in NAFLD are demonstrated, whereby both gained significantly in number in advanced stages, suggesting that the presence of autophagy-associated proteins and degenerated organelles within type1 NI plays a role in disease progression.
Intranuclear cytoplasmic inclusions in cytologically suspicious or malignant thyroid nodules: identification and correlation with echogenicity and size of the nodules
TLDR
It is concluded that ICI detection is associated with relatively smaller size and hypoechoic appearance in THY4 or THY5 nodules, and when coupled with these US characteristics, ICI identification selects lesions with high chances of malignancy.
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