Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.

Abstract

Liquid-liquid phase separation (LLPS) is believed to underlie formation of biomolecular condensates, cellular compartments that concentrate macromolecules without surrounding membranes. Physical mechanisms that control condensate formation/dissolution are poorly understood. The RNA-binding protein fused in sarcoma (FUS) undergoes LLPS in vitro and… (More)
DOI: 10.1016/j.cell.2018.03.003

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