Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer.

@article{FernndezMajada2007NuclearIA,
  title={Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer.},
  author={Vanessa Fern{\'a}ndez-Majada and Cristina Aguilera and Alberto Villanueva and Felip Vilardell and Alex Robert-Moreno and {\`A}lvaro Ayt{\'e}s and Francisco X Real and G. Capella and Marty W. Mayo and L. Manzano Espinosa and Anna Bigas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 1},
  pages={276-81}
}
Nuclear functions for IkappaB kinase (IKK), including phosphorylation of histone H3 and nuclear corepressors, have been recently described. Here, we show that IKK is activated in colorectal tumors concomitant with the presence of phosphorylated SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) corepressor that is aberrantly localized in the cytoplasm. In these tumors, IKKalpha associates to the chromatin of specific Notch targets, leading to the release of SMRT. Abrogation… CONTINUE READING

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