Nuclear Hormone Receptors and Their Ligands: Metabolites in Control of Transcription

@article{Tao2020NuclearHR,
  title={Nuclear Hormone Receptors and Their Ligands: Metabolites in Control of Transcription},
  author={Lian Jing Tao and Dong Eun Seo and Benjamin Jackson and Natalia B. Ivanova and F{\'a}bio Rinaldo Santori},
  journal={Cells},
  year={2020},
  volume={9}
}
Nuclear hormone receptors are a family of transcription factors regulated by small molecules derived from the endogenous metabolism or diet. There are forty-eight nuclear hormone receptors in the human genome, twenty of which are still orphans. In this review, we make a brief historical journey from the first observations by Berthold in 1849 to the era of orphan receptors that began with the sequencing of the Caenorhabditis elegans genome in 1998. We discuss the evolution of nuclear hormone… 

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