Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function.

@article{Belloni2009NuclearHB,
  title={Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function.},
  author={Laura Belloni and Teresa Pollicino and Francesca De Nicola and Francesca Guerrieri and Giuseppina Raffa and Maurizio Fanciulli and Giovanni Raimondo and Massimo Levrero},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 47},
  pages={19975-9}
}
HBV cccDNA, the template for transcription of all viral mRNAs, accumulates in the nucleus of infected cells as a stable episome organized into minichromosomes by histones and non-histone viral and cellular proteins. Using a cccDNA-specific chromatin immunoprecipitation (ChIP)-based quantitative assay, we have previously shown that transcription of the HBV minichromosome is regulated by epigenetic changes of cccDNA-bound histones and that modulation of the acetylation status of cccDNA-bound H3… CONTINUE READING
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Hepadnaviruses, in Fields Virology, eds Knipe DM, Howley PM (Lippincott

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