Nuclear Gene Indicates Coat-Color Polymorphism in Mammoths

  title={Nuclear Gene Indicates Coat-Color Polymorphism in Mammoths},
  author={Holger R{\"o}mpler and Nadin Rohland and Carles Lalueza-Fox and Eske Willerslev and Tatyana Kuznetsova and Gernot Rabeder and Jaume Bertranpetit and Torsten Sch{\"o}neberg and Michael Hofreiter},
  pages={62 - 62}
By amplifying the melanocortin type 1 receptor from the woolly mammoth, we can report the complete nucleotide sequence of a nuclear-encoded gene from an extinct species. We found two alleles and show that one allele produces a functional protein whereas the other one encodes a protein with strongly reduced activity. This finding suggests that mammoths may have been polymorphic in coat color, with both dark- and light-haired individuals co-occurring. 
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Nuclear DNA sequences from late Pleistocene megafauna.
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Genetics of hair and skin color.
  • J. Rees
  • Biology
    Annual review of genetics
  • 2003
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Resurrecting ancient genes: experimental analysis of extinct molecules
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It is shown that DNA molecules amplified by PCR from DNA extracted from animal bones and teeth that vary in age between 25 000 and over 50 000 years carry C-->T and G-->A substitutions, which are due to the occurrence of modified deoxycytidine residues in the template DNA.
Molecular ecology
  • Ych-chu Wang
  • Chemistry
    Journal of Northeast Forestry University
  • 2008
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We thank the members of our research groups and several anonymous reviewers for comments that improved the manuscript. This work was funded by the Max Planck Gesellschaft
  • Bundesministerium fü r Bildung, Wissenschaft, Forschung und Technologie and Deutsche Forschungsgemeinschaft. Sequences have been
PLoS Biol
  • PLoS Biol
  • 2006
Embo J
  • Embo J
  • 1996