Nuclear FoxO1 inflames insulin resistance.

  title={Nuclear FoxO1 inflames insulin resistance.},
  author={John E. Dominy and Pere B. Puigserver},
  journal={The EMBO journal},
  volume={29 24},
Chronic activation of macrophage-mediated inflammatory signals in insulin-sensitive metabolic tissues is thought to be one of the causes of insulin resistance—one of the hallmarks of the metabolic syndrome. However, the mechanisms, components and dynamics by which this inflammatory response is spatially and temporally regulated are not completely understood. In this issue of The EMBO Journal, Olefsky and colleagues (Fan et al, 2010) report that FoxO1, which is suppressed by the action of AKT… CONTINUE READING


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