Nuclear Factor I genomic binding associates with chromatin boundaries

  title={Nuclear Factor I genomic binding associates with chromatin boundaries},
  author={M. Pjanic and Christoph D. Schmid and A. Gaussin and G. Ambrosini and J. Adamcik and Petar Pjanic and Genta Plasari and Jan Kerschgens and G. Dietler and P. Bucher and N. Mermod},
  journal={BMC Genomics},
  pages={99 - 99}
  • M. Pjanic, Christoph D. Schmid, +8 authors N. Mermod
  • Published 2012
  • Biology, Medicine
  • BMC Genomics
  • BackgroundThe Nuclear Factor I (NFI) family of DNA binding proteins (also called CCAAT box transcription factors or CTF) is involved in both DNA replication and gene expression regulation. Using chromatin immuno-precipitation and high throughput sequencing (ChIP-Seq), we performed a genome-wide mapping of NFI DNA binding sites in primary mouse embryonic fibroblasts.ResultsWe found that in vivo and in vitro NFI DNA binding specificities are indistinguishable, as in vivo ChIP-Seq NFI binding… CONTINUE READING
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