Nuclear Factor 90, a cellular dsRNA binding protein inhibits the HIV Rev-export function

@article{UrcuquiInchima2006NuclearF9,
  title={Nuclear Factor 90, a cellular dsRNA binding protein inhibits the HIV Rev-export function},
  author={Silvio Urcuqui-Inchima and Mar{\'i}a Eugenia Casta{\~n}o and Dani{\'e}le Hernandez-Verdun and Georges St-Laurent and Ajit Kumar},
  journal={Retrovirology},
  year={2006},
  volume={3},
  pages={83 - 83}
}
The HIV Rev protein is known to facilitate export of incompletely spliced and unspliced viral transcripts to the cytoplasm, a necessary step in virus life cycle. The Rev-mediated nucleo-cytoplasmic transport of nascent viral transcripts, dependents on interaction of Rev with the RRE RNA structural element present in the target RNAs. The C-terminal variant of dsRNA-binding nuclear protein 90 (NF90ctv) has been shown to markedly attenuate viral replication in stably transduced HIV-1 target cell… CONTINUE READING

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Askjaer P: Rev protein and its cellular partners

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