Nuclear Factor-κB Activation: From Bench to Bedside

  title={Nuclear Factor-$\kappa$B Activation: From Bench to Bedside},
  author={Gautam Sethi and Bokyung Sung and Bharat Bhushan Aggarwal},
  journal={Experimental Biology and Medicine},
  pages={21 - 31}
Nuclear factor-κB (NF-κB) is a proinflammatory transcription factor that has emerged as an important player in the development and progression of malignant cancers. NF-κB targets genes that promote tumor cell proliferation, survival, metastasis, inflammation, invasion, and angiogenesis. Constitutive or aberrant activation of NF-κ is frequently encountered in many human tumors and is associated with a resistant phenotype and poor prognosis. The mechanism of such persistent NF-κB activation is… 

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