Nuclear Export of MicroRNA Precursors

@article{Lund2004NuclearEO,
  title={Nuclear Export of MicroRNA Precursors},
  author={Elsebet Lund and Stephan Güttinger and {\^A}ngelo Calado and James Eric Dahlberg and Ulrike Kutay},
  journal={Science},
  year={2004},
  volume={303},
  pages={95 - 98}
}
MicroRNAs (miRNAs), which function as regulators of gene expression in eukaryotes, are processed from larger transcripts by sequential action of nuclear and cytoplasmic ribonuclease III–like endonucleases. We show that Exportin-5 (Exp5) mediates efficient nuclear export of short miRNA precursors (pre-miRNAs) and that its depletion by RNA interference results in reduced miRNA levels. Exp5 binds correctly processed pre-miRNAs directly and specifically, in a Ran guanosine triphosphate–dependent… 

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