Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication

@inproceedings{Lahaye2016NuclearEP,
  title={Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication},
  author={Xavier Lahaye and Takeshi Satoh and Matteo Gentili and Silvia Cerboni and Aymeric Silvin and C{\'e}cile Conrad and Abdelhakim Ahmed-Belkacem and Elisa C. Rodriguez and Jean-François Guichou and Nathalie Bosquet and Matthieu Piel and Roger Le Grand and Megan C King and Jean-Michel Pawlotsky and Nicolas Manel},
  booktitle={Cell reports},
  year={2016}
}
During the early phase of replication, HIV reverse transcribes its RNA and crosses the nuclear envelope while escaping host antiviral defenses. The host factor Cyclophilin A (CypA) is essential for these steps and binds the HIV capsid; however, the mechanism underlying this effect remains elusive. Here, we identify related capsid mutants in HIV-1, HIV-2, and SIVmac that are restricted by CypA. This antiviral restriction of mutated viruses is conserved across species and prevents nuclear import… CONTINUE READING