Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication

Abstract

During the early phase of replication, HIV reverse transcribes its RNA and crosses the nuclear envelope while escaping host antiviral defenses. The host factor Cyclophilin A (CypA) is essential for these steps and binds the HIV capsid; however, the mechanism underlying this effect remains elusive. Here, we identify related capsid mutants in HIV-1, HIV-2… (More)
DOI: 10.1016/j.celrep.2016.03.074

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@inproceedings{Lahaye2016NuclearEP, title={Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication}, author={Xavier Lahaye and Takeshi Satoh and Matteo Gentili and Silvia Cerboni and Aymeric Silvin and C{\'e}cile Conrad and Abdelhakim Ahmed-Belkacem and Elisa C. Rodriguez and Jean-François Guichou and Nathalie Bosquet and Matthieu Piel and Roger Le Grand and Megan C. King and Jean-Michel Pawlotsky and Nicolas Manel}, booktitle={Cell reports}, year={2016} }