Nuclear Envelope Protein Lem2 is Required for Mouse Development and Regulates MAP and AKT Kinases

@inproceedings{Tapia2015NuclearEP,
  title={Nuclear Envelope Protein Lem2 is Required for Mouse Development and Regulates MAP and AKT Kinases},
  author={Olga Tapia and Loren G. Fong and Michael D. Huber and Stephen G. Young and Larry Gerace},
  booktitle={PloS one},
  year={2015}
}
The nuclear lamina, along with associated nuclear membrane proteins, is a nexus for regulating signaling in the nucleus. Numerous human diseases arise from mutations in lamina proteins, and experimental models for these disorders have revealed aberrant regulation of various signaling pathways. Previously, we reported that the inner nuclear membrane protein Lem2, which is expressed at high levels in muscle, promotes the differentiation of cultured myoblasts by attenuating ERK signaling. Here, we… CONTINUE READING