Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer

  title={Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer},
  author={Oscar Aguilera and Jos{\'e} Manuel Gonz{\'a}lez-Sancho and Sandra Zazo and R. Efra{\'i}n H. Rinc{\'o}n and Agust{\'i}n F Fern{\'a}ndez and Olga Tapia and Francesc V. Canals and Beatriz Morte and Vincenzo Calvanese and Jos{\'e} Luis Orgaz and N{\'u}ria Niell and Susana Aguilar and Jos{\'e} M P Freije and Osvaldo Gra{\~n}a and David G. Pisano and Aurea Borrero and Javier Martinez-Useros and Benilde Jim{\'e}nez and Mario F Fraga and Jes{\'u}s Miguel Garc{\'i}a-Foncillas and Carlos L{\'o}pez-Ot{\'i}n and Miguel Lafarga and Federico Cuesta Rojo and Alberto Mu{\~n}oz},
Sporadic colorectal cancer (CRC) insurgence and progression depend on the activation of Wnt/β-catenin signaling. Dickkopf (DKK)-1 is an extracellular inhibitor of Wnt/β-catenin signaling that also has undefined β-catenin-independent actions. Here we report for the first time that a proportion of DKK-1 locates within the nucleus of healthy small intestine and colon mucosa, and of CRC cells at specific chromatin sites of active transcription. Moreover, we show that DKK-1 regulates several cancer… CONTINUE READING
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Dickkopf-1 expression is downregulated along colorectal adenoma-carcinoma sequence and correlates with reduced microvessel density and VEGF expression

  • Z Liu, B Sun, +4 authors Y. Zhang
  • Histopathology. 2014; doi: 10.1111/his.12474…
  • 2014
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