Nuclear Cloning and Epigenetic Reprogramming of the Genome

@article{Rideout2001NuclearCA,
  title={Nuclear Cloning and Epigenetic Reprogramming of the Genome},
  author={W. Rideout and K. Eggan and R. Jaenisch},
  journal={Science},
  year={2001},
  volume={293},
  pages={1093 - 1098}
}
Cloning of mammals by nuclear transfer (NT) results in gestational or neonatal failure with at most a few percent of manipulated embryos resulting in live births. Many of those that survive to term succumb to a variety of abnormalities that are likely due to inappropriate epigenetic reprogramming. Cloned embryos derived from donors, such as embryonic stem cells, that may require little or no reprogramming of early developmental genes develop substantially better beyond implantation than NT… Expand
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Epigenetic reprogramming in mammalian nuclear transfer.
Nuclear cloning, stem cells, and genomic reprogramming.
Nuclear reprogramming in mammalian somatic cell nuclear cloning
Epigenetic reprogramming in cloned embryos.
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  • IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society
  • 2004
Epigenetic Mechanisms in Mammals and Their Effects on Cloning Procedures
Reshaping the transcriptional frontier: Epigenetics and somatic cell nuclear transfer
Asymmetric nuclear reprogramming in somatic cell nuclear transfer?
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2
3
4
5
...

References

SHOWING 1-10 OF 76 REFERENCES
Epigenetic Instability in ES Cells and Cloned Mice
Aberrant methylation of donor genome in cloned bovine embryos
Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle.
  • D. Betts, V. Bordignon, +4 authors W. King
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
Don't Clone Humans!
Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation
  • K. Eggan, H. Akutsu, +5 authors R. Jaenisch
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
Mice cloned from embryonic stem cells.
...
1
2
3
4
5
...