Nuclear Cloning and Epigenetic Reprogramming of the Genome

@article{Rideout2001NuclearCA,
  title={Nuclear Cloning and Epigenetic Reprogramming of the Genome},
  author={William C. Rideout and Kevin C Eggan and Rudolf Jaenisch},
  journal={Science},
  year={2001},
  volume={293},
  pages={1093 - 1098}
}
  • William C. Rideout, Kevin C Eggan, Rudolf Jaenisch
  • Published 2001
  • Biology, Medicine
  • Science
  • Cloning of mammals by nuclear transfer (NT) results in gestational or neonatal failure with at most a few percent of manipulated embryos resulting in live births. Many of those that survive to term succumb to a variety of abnormalities that are likely due to inappropriate epigenetic reprogramming. Cloned embryos derived from donors, such as embryonic stem cells, that may require little or no reprogramming of early developmental genes develop substantially better beyond implantation than NT… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 240 CITATIONS, ESTIMATED 54% COVERAGE

    Asymmetric nuclear reprogramming in somatic cell nuclear transfer?

    VIEW 2 EXCERPTS
    CITES BACKGROUND

    FILTER CITATIONS BY YEAR

    2002
    2020

    CITATION STATISTICS

    • 7 Highly Influenced Citations

    • Averaged 7 Citations per year from 2018 through 2020