Nuclear Cloning and Epigenetic Reprogramming of the Genome

@article{Rideout2001NuclearCA,
  title={Nuclear Cloning and Epigenetic Reprogramming of the Genome},
  author={William M Rideout and Kevin C Eggan and Rudolf Jaenisch},
  journal={Science},
  year={2001},
  volume={293},
  pages={1093 - 1098}
}
Cloning of mammals by nuclear transfer (NT) results in gestational or neonatal failure with at most a few percent of manipulated embryos resulting in live births. Many of those that survive to term succumb to a variety of abnormalities that are likely due to inappropriate epigenetic reprogramming. Cloned embryos derived from donors, such as embryonic stem cells, that may require little or no reprogramming of early developmental genes develop substantially better beyond implantation than NT… 
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