Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness.

  title={Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness.},
  author={Grahame J. McKenzie and P. Helen Stevenson and George Stagg Ward and Sofia Papadia and Hilmar Bading and Sangeeta Chawla and Martin L. Privalsky and Giles E Hardingham},
  journal={Journal of neurochemistry},
  volume={93 1},
Many neuronal processes require gene activation by synaptically evoked Ca(2+) transients. Ca(2+)-dependent signal pathways activate some transcription factors outright, but here we report that such signals also potentiate the activation of nuclear receptors by their cognate hormone, and of CBF1 by Notch, transcription factors hitherto not thought to be Ca(2+)-responsive. This potentiation is occluded by histone deacetylase inhibition, indicating a mechanism involving inactivation of co… CONTINUE READING