Nuclear Ca2+: physiological regulation and role in apoptosis

  title={Nuclear Ca2+: physiological regulation and role in apoptosis},
  author={Pierluigi Nicotera and Anna D. Rossi},
  journal={Molecular and Cellular Biochemistry},
The last decade has seen the rapid development of research investigating the molecular mechanisms whereby hormones, peptide growth factors and cytokines regulate cell metabolism, differentiation and proliferation. One general signalling mechanism used to transfer the information delivered by agonists into appropriate intracellular compartments involves the rapid Ca2+ redistribution throughout the cell, which results in transient elevations of the cytosolic free Ca2+ concentration. Ca2+ signals… CONTINUE READING


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