Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer.

@article{Tuncel2012NuclearAB,
  title={Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer.},
  author={Handan Tuncel and Fumio Shimamoto and Hiroshi Kaneko Guangying Qi and Eriko Aoki and Hiroshi Jikihara and Shiro Nakai and Takashi Takata and Masaaki Tatsuka},
  journal={Oncology letters},
  year={2012},
  volume={3 5},
  pages={1109-1114}
}
The chromosomal passenger complex (CPC) is a key regulator of chromosome segregation and cytokinesis, and consists of Aurora B kinase, INCENP, Survivin and Borealin. Aurora B is a member of a family of serine/threonine protein kinases, and Survivin belongs to the inhibitors of apoptosis (IAP) gene family, and is also a member of the CPC family. Aurora B and Survivin have also been reported to be overexpressed in various human cancers; however, as yet no studies have investigated the co… CONTINUE READING

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