Nuclear Arc Puts a Brake on Cocaine-Induced Chromatin Remodeling and Behaviors.


Psychostimulants, including cocaine, cause molecular adaptations in the nucleus of neurons, which include chromatin remodeling and altered gene transcription (1). These molecular adaptations have profound effects at the levels of the cell and circuitry, and ultimately in behavioral output (1). Numerous studies demonstrate altered transcription and chromatin… (More)
DOI: 10.1016/j.biopsych.2017.01.007