Nuciferine Relaxes Tracheal Rings via the Blockade of VDLCC and NSCC Channels.

@article{Yang2018NuciferineRT,
  title={Nuciferine Relaxes Tracheal Rings via the Blockade of VDLCC and NSCC Channels.},
  author={Xiao Ying Yang and Meng-Fei Yu and Jun Lei and Yong-bo Peng and Ping Zhao and Lu Xue and Weiwei Chen and Li-Qun Ma and Qing-Hua Liu and Jinhua Shen},
  journal={Planta medica},
  year={2018},
  volume={84 2},
  pages={83-90}
}
This study aimed to elucidate the mechanisms of nuciferine (a main aporphine alkaloid of lotus leaf extract), which can induce relaxation in contracted tracheal rings. Under Ca2+-free and 2 mM Ca2+ conditions, we found that nuciferine had no effect on the resting muscle tone of tracheal rings. In contrast, nuciferine relaxed high K+-contracted mouse… CONTINUE READING