NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization

@article{Raemaekers2003NuSAPAN,
  title={NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization},
  author={Tim Raemaekers and Katharina Ribbeck and Jo{\"e}l Beaudouin and Wim Annaert and Mark van Camp and Ingrid Stockmans and Nico Smets and R Bouillon and Jan Ellenberg and Geert Carmeliet},
  journal={The Journal of Cell Biology},
  year={2003},
  volume={162},
  pages={1017 - 1029}
}
Here, we report on the identification of nucleolar spindle-associated protein (NuSAP), a novel 55-kD vertebrate protein with selective expression in proliferating cells. Its mRNA and protein levels peak at the transition of G2 to mitosis and abruptly decline after cell division. Microscopic analysis of both fixed and live mammalian cells showed that NuSAP is primarily nucleolar in interphase, and localizes prominently to central spindle microtubules during mitosis. Direct interaction of NuSAP… CONTINUE READING
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